Innovative practice ability refers to the ability to raise, analyze and solve new problems. The innovation training project is a significant part of the quality project launched by the Chinese Ministry of Education, which provides an effective approach to cultivate innovative practice ability of college students. Focusing on the goal of promoting innovative practice ability, a “PSPC-CDIO” (project driven, student dominated, practice and training, and comprehensive assessment based on CDIO) mode for cultivating innovative practice ability is proposed. The application of innovative teaching and training demonstrates that the effectiveness of the “PSPC-CDIO” mode.