This study explores the experiences of an online and on-site (O2O) learning model of the seven international institution courses on Sustainable Development Goals from multidisciplinary fields. The paper explores what makes for effective teaching of sustainability within a multidisciplinary online and on-site context. This experience has impacted social, economic, and environmental sustainability from an engineering perspective. One of the learning outcomes of this course, as stated in CDIO Standard 3.0, is that students had interpersonal learning outcomes that focus on individual cognitive and affective development, such as personal and group interactions, teamwork, and communications in foreign languages. Opportunities are made available for students to study abroad and have international experiences such as internships and exchanges. This course is to practice the actual case studies from global communities in a collaborative manner. The 17 SDGs goals related to Smart Green Synergy were expecting to be understood by students. Member universities and research institutes give the online lecture presentation where students may have global insight into synergy, especially in the engineering implementation, leading to intelligent and green resources to overcome the climate change issue. The pandemic of the Covid-19 situation constrained the five universities in South East Asia to carry out online classes. In contrast, an on-site course was performing by Feng Chia University students with normal class activities. Students are encouraged to think critically to formulate problems, provide a solution internationally and define issues and solutions tailored to SDGs. Students' grade distribution showed a good result of achievement, which implied the expected learning outcomes had been achieved. Result analysis showed that from the 16.67% "Very Good" category in the mid-term, it increased to 42% in the final term. Other classes have decreased, but some are stable. Overall, there was an increase in the study results' improvement by approximately 150%.